KMID : 0356719980140040725
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Journal of the Korean Society of Coloproctology 1998 Volume.14 No. 4 p.725 ~ p.733
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A Study on the Relationship between CEA Immunohistochemical Findings and Expression Rate of PCNA and Clinicopathologic Factors of Colorectal Cancers
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Hong Kwan-Hee
Jun Byung-Min Kim Jong-Ik
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Abstract
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Immunohistochemical study was performed for CEA staining patterns and PCNA indices. And the relationship between immunohistochemical findings and well-known clinical prognostic factors on the purpose of the clinical usefulness was evaluated. In forty seven cases of surgically removed colorectal carcinomas, the results were as follows; CEA staining patterns were apical (17 cases) and cytoplasmic (30 cases) type. Carcinomas with cyto plasmic pattern for CEA revealed more advanced Dukes¡¯ stage and more undifferentiated type and higher incidence of lymph node metastasis and were correlated with increased serum CEA levels. But PCNA indices showed no correlation with the Dukes¡¯ stage, histologic grade and CEA staining patterns. The cytoplasmic pattern of CEA immunohistochemistry may be a useful marker suggesting more aggressive biologic behavior of the colorectal carcinomas.
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KEYWORD
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CEA (Carcinoembryonic antigen), PCNA (Proliferating cell nuclear antigen), Colorectal carcinoma
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